How does Pseudoexfoliation Syndrome lead to Glaucoma?
In pseudoexfoliation syndrome, a flaky, dandruff-like protein builds up on the lens and other structures inside the eye. As the iris moves, it rubs this material and pigment loose, and the debris clogs the trabecular meshwork — the eye’s drain. Pressure can climb high and erratically, so pseudoexfoliation glaucoma often behaves more aggressively than ordinary open-angle glaucoma and needs closer monitoring. The same material weakens the fibers that support the lens, which matters for planning future cataract surgery. Regular pressure checks and dilated exams are essential.
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Pseudoexfoliation syndrome is a condition that is caused by tiny flakes that build up in the front of the eye. This fibrillar material is deposited on the the lens of the eye and also in the trabecular meshwork of the eye where the fluid drains out. In some patients this can block the outflow of the fluid in the eye, raising the eye pressure and causing glaucoma. Not all people with Pseudoexfoliation syndrome develop glaucoma. It is common for one eye to develop this condition earlier than the other eye, but both eyes are at risk for glaucoma if Pseudoexfoliation material is present. If you have Pseudoexfoliation syndrome, your chances of developing glaucoma are about six times higher than people who do not have it. Your doctor will perform a careful exam of the lens after your pupils are dilated to detect the subtle signs of Pseudoexfoliation. Remember that caring for your eyesight begins with complete eye examinations. A comprehensive evaluation is the best way to detect eye conditions such as glaucoma early, so that it can be addressed before it develops into something more serious.
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This page and video are for general patient education and are not a substitute for a medical examination, diagnosis, or treatment. Eye conditions vary by individual. For advice about your eyes, schedule an evaluation with May Eye Care Center. In an emergency, call 911.
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